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UOXFi001-D

MK071-6

iPSC line

Not-for-profit fee: £1400 per vial
Stock not immediately available - enquire for details
A CLIP contains information about a cell line including any specific third party obligations relating to, for example, licensing obligations or the donor consent which affect the use of the cell line.

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General#

Cell Line

hPSCreg name UOXFi001-D
Alternative name(s)
MK071-6
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
UOXFi001-B
(MK071-3)
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GBA1
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Parkinson disease
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STBCi084-A
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STBCi025-C
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STBCi085-A
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STBCi088-A
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UOXFi003-A
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GBA1
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UOXFi003-C
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UOXFi002-B
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STBCi084-B
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Parkinson disease
STBCi042-A
(SFC848-03-02)
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GBA1
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Parkinson disease
STBCi042-B
(SFC848-03-04)
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GBA1
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Parkinson disease
STBCi042-C
(SFC848-03-06)
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GBA1
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STBCi085-B
(SFC866-03-02)
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GBA1
Donor diseases:
Parkinson disease
STBCi085-C
(SFC866-03-05)
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GBA1
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Parkinson disease
STBCi088-B
(SFC872-03-02)
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GBA1
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Parkinson disease
STBCi088-C
(SFC872-03-03)
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STBCi004-B-1
(SFC832-03-06 LRRK2WT/WT C47)
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LRRK2
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ESi004-A
([GD]FiPS-4F-21c)
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GBA1
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Gaucher disease
STBCi024-A
(SFC831-03-01)
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STBCi024-C
(SFC831-03-05)
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STBCi019-C
(SFC828-03-04)
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STBCi004-A
(SFC832-03-19)
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EDi001-A-1
(AST22-C, AST23-C)
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EDi001-A-2
(AST23-1KO-3, AST22-1KO-3, AST-23_SCAKO Clone 3, AST-22_SNCAKO Clone 3)
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SNCA, SNCA, SNCA, SNCA
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Parkinson disease
EDi001-A-3
(AST23_SNCAKO Clone 1, AST22-1KO-1, AST23-1KO-1, AST22_SNCAKO Clone 1)
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SNCA, SNCA, SNCA, SNCA
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Parkinson disease
STBCi267-A
(SFC027-03-02)
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STBCi023-B
(SFC829-03-04)
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STBCi320-A
(SFC031-03-03)
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Parkinson disease
STBCi005-A
(SFC833-03-01)
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LRRK2
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Parkinson disease
STBCi007-A
(SFC855-03-06)
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LRRK2
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Parkinson disease
STBCi083-B
(SFC830-04-08)
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SNCA
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Parkinson disease
EDi001-A
(AST22, AST23, SAMEA3319992)
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SNCA, SNCA, SNCA
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Parkinson disease
UOXFi007-A
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UOXFi008-A
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UOXFi008-B
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LRRK2
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UOXFi010-C
(JR023-5)
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Parkinson disease
ESi002-A
(SP08#1)
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Parkinson disease
ESi006-A
(SP13#4)
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LRRK2
Donor diseases:
Parkinson disease
STBCi004-B
(SFC832-03-06)
Donor's gene variants:
LRRK2
Donor diseases:
Parkinson disease
STBCi004-C
(SFC832-03-07)
Donor's gene variants:
LRRK2
Donor diseases:
Parkinson disease
STBCi266-A
(SFC072-03-06)
Donor diseases:
Parkinson disease
STBCi019-A
(SFC828-03-06)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
STBCi019-B
(SFC828-03-09)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
STBCi278-A
(SFC245-03-08)
Donor diseases:
Parkinson disease
STBCi280-A
(SFC066-03-01)
Donor diseases:
Parkinson disease

Provider

Depositor University of Oxford (UOXF)
Distributors
EBiSC

External Databases

hPSCreg UOXFi001-D
BioSamples SAMEA4454476
Cellosaurus CVCL_EE30
Wikidata Q54991435

General Information

This EBiSC line can be used for:
Yes
Research use: allowed
Clinical use: no
Commercial use: no

Donor Information#

General Donor Information

Sex female
Age of donor (at collection) 70-74

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation and affected.
Synonyms
  • Parkinson disease
  • Parkinson's disease
  • paralysis agitans
Genetic variants
GBA1 (target)
1q22
NM_000157.3:c.1226A>G
NP_000148.2:p.Asn409Ser
Heterozygous
Heterozygous GBA N370S. N322S; ASN370SER

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
No

Donor Relations

Other cell lines of this donor

External Databases (Donor)

BioSamples SAMEA4453898

hIPSC Derivation#

General

Source cell type
Any skin fibroblast that is part of some dermis.
Source cell origin
Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.
Synonyms
  • portion of skin
  • region of skin
  • skin
  • skin region
  • skin zone
show more synonyms
Age of donor (at collection) 70-74
Collected in 2011
Passage number reprogrammed 4

Reprogramming method

Vector type Integrating
Vector Virus (Retrovirus)
Genes
Is the used vector excisable?
No
Absence of reprogramming vector(s)?
Yes
Reprogramming vectors silenced?
Yes
Methods used
RT-PCR

Vector free reprogramming

Other

Selection criteria for clones Morphology
Derived under xeno-free conditions
No
Derived under GMP?
No
Available as clinical grade?
No

Culture Conditions#

The following are the depositor culture conditions, they do not refer to any specific batch.
Surface coating Matrigel/Geltrex
Feeder cells
No
Passage method Enzyme-free cell dissociation
EDTA
O2 Concentration 20 %
CO2 Concentration 5 %
Medium mTeSR™ 1

Characterisation#

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
TRA 1-60
Yes
Pluripotency Score Novelty Score
22.39 1.44
Morphology pictures

Genotyping#

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46, XX
Passage number: 13
Karyotyping method: Illumina Human CytoSNP-12v2.1 bead chip array

Other Genotyping (Cell Line)