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StemBANCC – Stem cells for biological assays of novel drugs and predictive toxicology (IMI project)
StemBANCC aims to provide well characterised patient derived induced pluripotent stem cell lines and associated biomaterials in an accessible and sustainable bio-bank. StemBANCC also aims to demonstrate proof of concept for the utility of induced pluripotent stem cells in drug discovery for hard-to-treat disorders.
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EU-AIMS - European Autism Interventions - a Multicentre Study for Developing New Medications
EU-AIMS is the largest single grant for autism in the world, and the largest for the study of any mental health disorder in Europe. EU-AIMS involves a novel collaboration between organisations representing affected individuals and their families (Autism Speaks), academia and industry who for the first time in the world have come together to develop the infrastructure underpinning new treatments for autism. Patient organizations, academia and industry join forces to develop and assess novel treatment approaches for autism.
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HipSci - Human Induced Pluripotent Stem Cells Initiative
HipSci brings together diverse constitutents in genomics, proteomics, cell biology and clinical genetics to create a UK national iPSC resource and use it to carry out cellular genetic studies.
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SCR&Tox – Stem cells for relevant efficient extended and normalized toxicology
SCR&Tox aims to develop methods to predict the toxicity of drugs and cosmetics _in tissues derived from pluripotent stem cells. “We will measure if cellular pathways within tissues are altered by chronic exposure to these products, focusing on five organs: the liver, heart, skin, nervous system and musculoskeletal system.
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MIP-DILI – Mechanism Based Integrated Systems for the Prediction of Drug Induced Liver Injury
Drug Induced Liver Injury is a major health problem with broad implications for patients, health care professionals, the pharmaceutical industry and drug regulatory agencies. The current test systems employed by the pharmaceutical industry are poorly predictive for DILI. The Mechanism Based Integrated Systems for the Prediction of Drug Induced Liver Injury (MIP-DILI) project will address this situation by the development of innovative preclinical test systems.
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