The EBiSC Catalogue is a collection of human iPS cells being made available to academic and commercial researchers for use in disease modelling and other forms of preclinical research.
The initial collection has been generated from a wide range of donors representing specific disease backgrounds and healthy controls. As the collection grows, more isogenic control lines will become available which will add further to the collection’s appeal.
Cell lines in the current EBiSC catalogue have been made and deposited by EBiSC partner labs and a number of external organisations. This currently includes neurodegenerative diseases (Frontotemporal Dementia, Motor Neurone Disease (ALS) - and Huntington’s Disease), eye and heart diseases, and lines from healthy control donors for age and sex matching. During the next months, new cell lines will enter the catalogue through collaborations with partner research consortia and through new cell line creation from within the EBiSC consortium. This will see a large number of Parkinson’s and Alzheimer’s Disease lines being introduced together with lines for diabetes and cardiovascular research as well as muscular dystrophies and neuropathic pain.
In addition to the quality assured iPS cell lines in the collection, EBiSC is also establishing an Information Management System (IMS). The IMS is the portal through which external users (both depositors and customers) can access information linked to the cell lines. Initially users may use this information to decide which lines are the most appropriate for their intended research question. It is our intention to enable future updating of this information to, for example give additional genotypic information which may be of interest (eg. ApoE subtypes on lines used for Alzheimer’s research) as well as details of which directed differentiation protocols have been successfully applied to the cells.