Cell Line Collection: IPMAR Alzheimer’s disease

Late-onset Alzheimer’s disease (AD) has a high genetic contribution, estimated to be 60-80% of risk, and common forms of AD are highly polygenic. In the IPMAR Resource (iPSC Model for Alzheimer’s disease Research), we have captured the polygenicity of common AD in a large collection of iPSC lines reprogrammed from: (a) research-diagnosed late-onset AD with extremely high polygenic risk for AD, and (b) elderly cognitively healthy controls with extremely low polygenic risk for AD. Polygenic risk was quantified for individuals in the Cardiff AD cohort using a global AD polygenic risk score (Leonenko et al, 2021, doi: 10.1038/s41467-021-24082-z), which is effective for predicting individuals that will develop AD (Escott-Price et al, 2017, doi: 10.1002/ana.24999), and extremes of polygenic risk score were selected above or below 1.8 S.D. The iPSC lines have an associated dataset of anonymized clinical, cognitive and non-cognitive longitudinal data and genome-wide microarray data (Illumina 610 or global screening array), which is available upon application via the Dementia Platforms UK website ( https://portal.dementiasplatform.uk ). The Dementias Platform UK have also developed a data discovery tool that allows the iPSC lines to be filtered for parameters such as age of onset, sex, APOE ε-allele genotype, and polygenic risk score, which can be accessed here: https://portal.dementiasplatform.uk/projects/IPMAR .