Main work groups
To ensure that the EBiSC2 project meets its main objective in establishing sustainable operations of an EU-based iPSC banking operation, different work groups have been established to carry out the complex research activities planned.
EFPIA group: In addition to the provision of financial support, pharmaceutical company partners led by Janssen will contribute "in kind" to the project through provision of cell lines and data, as well as their scientific expertise and extensive business experience in applied iPSC research for drug development purposes, to ensure that EBiSC will meet the diverse, commercial user needs for iPSC lines.
iPSC Centres: The EBiSC consortium includes specialist iPSC centres from academia, small enterprises and not-for-profit organisations, which have an established track record in the generation of new iPSC lines and direct connections with clinical and patient groups. This will allow EBiSC to rapidly access iPSC lines and disease-specific tissues from a variety of European sources. iPSC Centres will generate new iPSC cell lines and deposit them into the EBiSC bank.
EBiSC iPSC facilities: The ECACC facility is at Porton Down (Salisbury, UK). The mirror facility at Fraunhofer IBMT (Sulzbach, Germany) will provide comprehensive operational back up. Read more about the bank facilities »
Bio-engineering & automation: These activities are led by Fraunhofer IBMT to evaluate and develop improved stem cell culture and cryopreservation systems.
iPSC Differentiation: Additional services such as bulk production of hiPSCs and delivery of pre-differentiated cell populations will be developed with input from academic, non-profit and commercial partners to facilitate the use of hiPSC in research.
Quality Control & Characterisation: By delivering standardised high quality, cost effective and rapid scientific characterisation data for the banked iPSC lines, Fraunhofer IBMT and ECACC ensure that EBiSC meets the standard of quality required by the end-users.
Distribution & commerce: The European Cell Culture Collection (ECACC) of Public Health England (Department of Health, UK) will store distributable iPSC lines, process orders via their e-commerce platform and coordinate cell line distribution.
Legal & Ethics group: A legal and ethical framework established in the first project phase will be maintained and further developed with input from industry experts to ensure a responsible and responsive governance framework that will optimise the utility and longevity of the Bank by establishing robust documentation for donor consent, material deposition and end user agreements for academic and commercial use, in line with the IMI's requirements. This will include generation, deposit and distribution of iPSC lines for commercial use.
Information Management System (IMS): The EBiSC IMS allows users to submit, search and retrieve a rich collection of data on each iPSC line banked, and will be further developed by Charite[RS1] to improve search functions, linkage to datasets and to increase the breadth and depth of datasets available.
Project management: The Project Administration Office provided by ARTTIC supports the Project Coordination team in the project administration and the reporting to IMI-JU and serves as contact point for the consortium partners for various matters. ARTTIC also supports the different dissemination activities of the consortium.
In addition, EBiSC will benefit from scientific and ethical advice provided by independent international experts.