What is hPSCreg?
hPSCreg is a global registry for human pluripotent stem cell lines (hPSC-lines). It aims to provide to the community
- a central and searchable hub for available hPSC-lines
- a central registry of clinical studies based on hPSC-lines
- a standardized identifier for hPSC-lines and register of these standard names
- a trustworthy data source for hPSC-lines by verifying the ethical and biological conformity of registered lines based on community standards
- comparability of quality standards in hPSC research
- certification of quality and ethical provenance of hPSC-lines
- a platform where any scientist or institution generating or working with PSC lines can register their cell lines, projects or clinical studies
Why register cell lines?
- establishes a standard name and unique identifier for the cell line, making it recognizable throughout publication and data resources.
- verifies ethical provenance and scientific evidence for pluripotency using standardized criteria
- offers access to information related to the individual PSC-lines such as derivation, cultivation, genetic constitution and application
- provides secure, findable and unrestricted storage of valuable data on hPSC-lines
- guarantees global visibility, confidence in ethical provenance, validation of characterization data, and comparability with other registered lines
What is registered?
- almost all information related to hPSC-lines, including ethical provenance, procurement, derivation process, genetic and expression data and other molecular or biological characteristics, use, and quality of the line can be registered.
- data and information on each line can be updated, edited and completed.
- more information on data quality and data standards can be found in this webinar: https://www.youtube.com/watch?v=iz2z5ztCZXg
Why register research projects in hPSCreg?
- establishes a transparent link between a research project and qualified hPSC-lines that are registered in hPSCreg
- promotes transparency of hPSC line usage in publicly or privately funded research projects
What is the Clinical study registry for hPSC-based cell therapies?
The clinical study registry aims at providing a comprehensive overview of clinical studies that specifically use human pluripotent stem cells (hPSC) or hPSC-derived cells. These include human embryonic stem cells (hESC), human induced pluripotent stem cells (hiPSC), stem cells created by stem cell nuclear transfer (SCNT) and parthenogenetic stem cells, comprising trials worldwide where patients are actively treated with hPSC – derived cells or a product thereof.
Registration of clinical studies in hPSCreg is (a) based on information retrieved from multiple public resources and (b) based on information provided by individual study teams.
The registry also provides links to the original source of the information (i.e. clinical trial registries worldwide) and will facilitate the unique identification of trials by grouping together multiple records about the same trial.
Why register clinical studies in hPSCreg?
- tracks the translational pathway of hPSCs to clinical application
- specifically highlights the progress of hPSC-derived cell therapies across multiple regulatory jurisdictions
Collaboration and Cooperation
hPSCreg offers an open platform for coordination and cooperation in the area of hPSC research and application, thus avoiding redundancy and promoting reproducibility in research. hPSCreg collaborates with registries, cell banks and international initiatives worldwide.
History and funding
hPSCreg was established in 2007 as the European human embryonic stem cell registry (hESCreg) and is supported by the European Commission. You can also find hPSCreg at re3data.org, FAIRsharing.org, and Identifiers.org. Should you experience any problems interacting with the database or would like to contribute to its further development please contact us.
- Isasi R et al. A pathway for attesting ethical provenance of cell lines: Lessons from the European human pluripotent stem cell registry (hPSCreg). Stem cell research. 2019 Oct;40:101539.
- Guhr A et al. Recent Trends in Research with Human Pluripotent Stem Cells: Impact of Research and Use of Cell Lines in Experimental Research and Clinical Trials. Stem cell reports. 2018 Aug 14;11(2):485-496.
- Kurtz A et al. A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells. Stem cell reports. 2018 Jan 9;10(1):1-6.
- Kim JH et al. Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. Stem cells translational medicine. 2017 Nov;6(11):1956-1962.
- De Sousa PA et al. Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience. Stem cell research. 2017 Apr;20:105-114.
- Seltmann S et al. hPSCreg--the human pluripotent stem cell registry. Nucleic acids research. 2016 Jan 4;44(D1):D757-63.
- Sermon KD et al. Creation of a registry for human embryonic stem cells carrying an inherited defect: joint collaboration between ESHRE and hESCreg. Human reproduction (Oxford, England). 2009 Jul;24(7):1556-60.
- Elstner A et al. The changing landscape of European and international regulation on embryonic stem cell research. Stem cell research. 2009 Mar;2(2):101-7.
- Borstlap J et al. Development of a European human embryonic stem cell registry. Regenerative medicine. 2008 Nov;3(6):945-51.
- Borstlap J et al. First evaluation of the European hESCreg. Nature biotechnology. 2008 Aug;26(8):859-60.