Main work groups
To ensure that the EBiSC project meets its main objective in demonstrating an EU-based iPSC banking operation, different work groups have been established to carry out the complex research activities planned.
EFPIA group: In addition to the provision of financial support, the group of six pharmaceutical companies led by Pfizer will contribute “in kind” to the project mainly with cell lines and data, as well as with their scientific expertise and extensive business experience in applied iPSC research for drug development purposes, so as to ensure that EBiSC will meet the diverse, commercial user needs for iPSC lines.
iPSC Centres: The EBiSC consortium currently comprises eight centres from academia, small enterprises and not-for-profit organisations, which have an established track record in the generation of new iPSC lines and direct connections with clinical and patient groups. This will allow EBiSC to rapidly access iPSC lines and disease-specific tissues from a variety of European sources. iPSC Centers will generate new iPSC cell lines and deposit them into the EBiSC bank.
EBiSC iPSC facilities: The main facility led by Roslin Cells will be at the Babraham Research Campus (Cambridge, UK) and will undertake cell expansion, quality control and characterisation. The mirror facility at Fraunhofer IBMT (Sulzbach, Germany) will provide comprehensive operational back up. Read more about the bank facilities »
Bio-engineering & automation: These activities are led by the Fraunhofer IBMT to evaluate and develop improved stem cell culture and cryopreservation systems.
Quality Control & Characterisation: By delivering standardised high quality, cost effective and rapid scientific characterisation data for the banked iPSC lines, this work group will ensure that EBiSC meets the standard of quality required by the end-users.
Distribution & commerce: The European Cell Culture Collection (ECACC) of Public Health England (Department of Health, UK) will store distributable iPSC lines, process orders via their e-commerce platform and coordinate cell line distribution.
Legal & Ethics group: Legal and ethical scholars from the universities of Edinburgh and Hannover will work closely with all project partners to ensure a responsible and responsive governance framework that will optimise the utility and longevity of the Bank by establishing robust documentation for donor consent, material deposition and end user agreements for academic and commercial use, in line with the IMI’s requirements.
Information Management System (IMS): To develop and maintain a repository of iPSC lines for commercial and research use, a robust IMS will be developed which allows users to submit, search and retrieve a rich collection of data on each iPSC line banked.
Project management: The Project Administration Office provided by ARTTIC supports the Project Coordination team in the project administration and the reporting to IMI-JU and serves as contact point for the consortium partners for various matters. ARTTIC support also the different dissemination activities of the consortium.
In addition, EBiSC will benefit from scientific and ethical advice provided by independent international experts.